Intercellular communication via gap junction channels between chondrocytes and bone cells
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We have demonstrated in collaboration with Virgis Valiunas and Peter Brink, that synovial cells, bone cells and chondrocytes are able to communicate through gap junction channels formed by Cx43, exchanging ions, small molecules, peptides and proteins probably also via exosomes or nanotubes. These results are important to understand synovial-cartilage-bone communication and will help to understand the mechanisms involved in joint degeneration in disorders such as osteoarthritis.